Irradiation-free re-conditioning in children following graft failure of a T cell-depleted graft from a haploidentical parent
نویسندگان
چکیده
منابع مشابه
T cell depleted haploidentical transplantation: positive selection
Interest in mismatched transplantation arises from the fact that a suitable one-haplotype mismatched donor is immediately available for virtually all patients, particularly for those who urgently need an allogenic transplant. Work on one haplotype-mismatched transplants has been proceeding for over 20 years all over the world and novel transplant techniques have been developed. Some centres hav...
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The prognosis of patients affected by myelofibrosis (MF) is usually dismal and allogeneic hematopoietic stem cell transplantation (HSCT) remains the only cure. The number of HSCTs in MF patients has recently increased. However, a major obstacle is still represented by primary graft failure (PGF). Currently there are no definitive guidelines for the treatment of PGF and a second HSCT can be perf...
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Allogeneic haematopoietic stem cell transplantation (HSCT) from an human leukocyte antigen (HLA)-identical donor can be curative for eligible patients with non-malignant and malignant haematological disorders. HSCT from alternative donor sources, such as HLA-mismatched haploidentical donors, is increasingly considered as a viable therapeutic option for patients lacking HLA-matched donors. Initi...
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Outcomes of allogeneic hematopoietic stem cell transplantation (AHSCT) using HLA-half matched related donors (haploidentical) have recently improved due to better control of alloreactive reactions in both graft-versus-host and host-versus-graft directions. The recognition of the role of humoral rejection in the development of primary graft failure in this setting has broadened our understanding...
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For many critical cardiac conditions such as cardiomyopathy, congenital heart defects, or arrhythmogenic disorders, cardiac transplantation is often an accepted treatment with optimistic oneand five-year survival rates of 90% and 75% in the pediatric patient population, respectively. However, poor longterm survival is a cause for concern, with cardiac graft failure being the leading cause in la...
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ژورنال
عنوان ژورنال: Bone Marrow Transplantation
سال: 2021
ISSN: 0268-3369,1476-5365
DOI: 10.1038/s41409-020-01196-4